Water Transporters: How So Fast Yet So Selective?
نویسندگان
چکیده
A high-resolution X-ray structure of an aquaporin has revealed water molecules bound within the transmembrane pore and provided new clues to the mechanisms of rapid water transport and high selectivity in this important class of membrane proteins.
منابع مشابه
The dynamics and energetics of water permeation and proton exclusion in aquaporins.
Aquaporins and aquaglyceroporins are passive membrane channels that, in many species, facilitate highly efficient yet strictly selective permeation of water and small solutes across lipid bilayers. Their ability to block proton flux is particularly remarkable, because other aqueous pores and water efficiently conduct protons, via the so-called Grotthuss mechanism. How efficient water permeation...
متن کاملO21: Aquaporinopathy and Cerebral Inflammation
Many mammalian AQPs, including AQP1, AQP2, AQP4, AQP5 and AQP8, function primarily as bidirectional water-selective transporters. Cells expressing AQPs on their plasma membrane have an ~5- to 50-fold higher osmotic water permeability than membranes that do not. Water transport through single-file pores poses a biophysical limitation on the efficiency with which AQPs can transport water, so that...
متن کاملThe Source of Human Knowledge: Plato’s problem and Orwell’s problem
Chomsky cannot help wondering at the fact that we, despite so vast evidence, have little knowledge about the obvious evidence. A good example, I think, is the child’s way of first language acquisition. A great many researchers have studied various aspects of child language acquisition at different stages of the child’ life and have brought to light many details of language development. However,...
متن کاملThe Source of Human Knowledge: Plato’s problem and Orwell’s problem
Chomsky cannot help wondering at the fact that we, despite so vast evidence, have little knowledge about the obvious evidence. A good example, I think, is the child’s way of first language acquisition. A great many researchers have studied various aspects of child language acquisition at different stages of the child’ life and have brought to light many details of language development. However,...
متن کاملInsect glycerol transporters evolved by functional co-option and gene replacement
Transmembrane glycerol transport is typically facilitated by aquaglyceroporins in Prokaryota and Eukaryota. In holometabolan insects however, aquaglyceroporins are absent, yet several species possess polyol permeable aquaporins. It thus remains unknown how glycerol transport evolved in the Holometabola. By combining phylogenetic and functional studies, here we show that a more efficient form of...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Current Biology
دوره 12 شماره
صفحات -
تاریخ انتشار 2002